In clinical trials in adults, eating coconut oil raised LDL cholesterol more than non-tropical vegetable oils did, so coconut oil and a non-tropical oil such as sesame oil are not interchangeable ghee replacements in their effect on blood lipids.
Moderate certainty
Further research may change the size of the effect.Who this is about
adults
Practical note
Graded moderate: a 2020 meta-analysis of 16 trial articles lasting at least 2 weeks, with the effect holding after excluding non-randomised and lower-quality trials; downgraded once for inconsistency (I2 84%). The trials compared coconut oil with other cooking fats, not with ghee directly.
Vegan note
Coconut oil is a common vegan stand-in for ghee; non-tropical plant oils such as sesame oil had the more favourable LDL profile in these trials.
Safety note
Coconut oil is high in saturated fat; the trials found higher LDL cholesterol than with non-tropical vegetable oils, alongside a rise in HDL cholesterol and no clear effect on glycaemia, inflammation or adiposity markers.
Sources
- Supports “Coconut oil consumption results in significantly higher LDL-cholesterol than nontropical vegetable oils.” (Abstract, Conclusions) Neelakantan N, Seah JYH, van Dam RM. 2020. Circulation. The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine
- Context “Coconut oil consumption significantly increased LDL-cholesterol by 10.47 mg/dL (95% CI: 3.01, 17.94; I2 = 84%, N=16)” (Abstract, Results) Neelakantan N, Seah JYH, van Dam RM. 2020. Circulation. The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine