In a small randomised trial, healthy volunteers trained for ten days in the Wim Hof method (cyclic hyperventilation followed by breath retention, cold exposure and meditation) showed lower pro-inflammatory cytokines and fewer flu-like symptoms after an experimental endotoxin challenge than untrained controls.
Low certainty
Further research is likely to change this.Who this is about
healthy adult volunteers
Practical note
Graded low: one randomised trial of 24 healthy volunteers, unblinded, measuring a laboratory response to injected endotoxin; the training combined breathing, cold immersion and meditation, so the share due to breath retention is unknown. A 2024 systematic review of eight trials was positive about inflammation but did not pool results.
Vegan note
Not diet-related; applies equally to people following a vegan diet.
Safety note
The breathing produced intermittent low blood oxygen. It should never be practised in or near water, including ice baths, because of the risk of blackout and drowning. People who are pregnant or living with heart, lung or mental-health conditions are generally advised to check with a health professional first.
Sources
- Supports “Levels of proinflammatory mediators TNF-α, IL-6, and IL-8 were lower in the intervention group and correlated negatively with IL-10 levels. Finally, flu-like symptoms were lower in the intervention group.” (Abstract) Kox M, van Eijk LT, Zwaag J, van den Wildenberg J, Sweep FC, van der Hoeven JG, Pickkers P. 2014. Proceedings of the National Academy of Sciences of the United States of America. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine
- Supports “The findings suggest that the WHM may reduce inflammation in healthy and non-healthy participants as it increases epinephrine levels, causing an increase in interleukin-10 and a decrease in pro-inflammatory cytokines.” (Abstract, Results) Almahayni O, Hammond L. 2024. PLoS One. Does the Wim Hof Method have a beneficial impact on physiological and psychological outcomes in healthy and non-healthy participants? A systematic review. CC BY 4.0; credit Almahayni and Hammond, PLoS One 2024; Courtesy of the U.S. National Library of Medicine
- Context “Subjects in the intervention group were trained for 10 d in meditation (third eye meditation), breathing techniques (i.a., cyclic hyperventilation followed by breath retention), and exposure to cold (i.a., immersions in ice cold water).” (Abstract) Kox M, van Eijk LT, Zwaag J, van den Wildenberg J, Sweep FC, van der Hoeven JG, Pickkers P. 2014. Proceedings of the National Academy of Sciences of the United States of America. Voluntary activation of the sympathetic nervous system and attenuation of the innate immune response in humans. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine