In older adults, daily calcium combined with vitamin D, as part of a healthy lifestyle, may help reduce the risk of fractures by a small amount, while trials of vitamin D alone found no reduction; trial results are inconsistent and the trials at lowest risk of bias found no effect.
Low certainty
Further research is likely to change this.Who this is about
older adults
Practical note
Graded low: randomised evidence, downgraded for inconsistency (a 2019 pooled analysis of 6 trials found a 6 percent lower risk of any fracture and 16 percent lower hip fracture risk, but the WHI trial and the 2015 lowest-risk-of-bias trials found no significant effect) and for likely publication bias. Combined trials used calcium at 1000-1200 mg a day with vitamin D at 400-800 IU a day.
Safety note
See the claim on kidney stones and heart attack for the risks reported with calcium supplements.
Sources
- Supports “combined supplementation with vitamin D (daily doses of 400-800 IU, yielding a median difference in 25[OH]D concentration of 9.2 ng/mL) and calcium (daily doses of 1000-1200 mg) found a 6% reduced risk of any fracture (RR, 0.94; 95% CI, 0.89-0.99) and a 16% reduced risk of hip fracture (RR, 0.84; 95% CI, 0.72-0.97).” (Abstract, Results (sentence on the 6 RCTs of combined vitamin D and calcium; excerpt from its second clause)) Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R. 2019. JAMA Network Open. Vitamin D and Calcium for the Prevention of Fracture: A Systematic Review and Meta-analysis. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine
- Opposes “In randomised controlled trials at lowest risk of bias (four studies, n=44,505), there was no effect on risk of fracture at any site.” (Abstract, Results) Bolland MJ, Leung W, Tai V, Bastin S, Gamble GD, Grey A, Reid IR. 2015. BMJ. Calcium intake and risk of fracture: systematic review. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine
- Context “Among healthy postmenopausal women, calcium with vitamin D supplementation resulted in a small but significant improvement in hip bone density, did not significantly reduce hip fracture, and increased the risk of kidney stones.” (Abstract, Conclusions) Jackson RD, LaCroix AZ, Gass M, et al.; Women's Health Initiative Investigators. 2006. New England Journal of Medicine. Calcium plus vitamin D supplementation and the risk of fractures. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine