In adults, the activity of thousands of genes in white blood cells and fat tissue varies with the season, with a more pro-inflammatory immune profile in winter, and the seasonal pattern is inverted between Europe and Oceania.
Low certainty
Further research is likely to change this.Who this is about
adults in cohorts in Europe, Oceania and The Gambia
Practical note
The study reported more than 4,000 protein-coding genes with seasonal expression profiles. Graded low: a single observational analysis, indirect to any seasonal routine.
Safety note
Descriptive observational finding; it shows that physiology changes with the seasons, not that any seasonal regimen changes it.
Sources
- Supports “Here we find more than 4,000 protein-coding mRNAs in white blood cells and adipose tissue to have seasonal expression profiles, with inverted patterns observed between Europe and Oceania.” (Abstract) Dopico XC, Evangelou M, Ferreira RC, Guo H, Pekalski ML, Smyth DJ, Cooper N, Burren OS, Fulford AJ, Hennig BJ, Prentice AM, Ziegler AG, Bonifacio E, Wallace C, Todd JA. 2015. Nature Communications. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. CC BY; credit Dopico et al., Nature Communications 2015
- Context “the immune system has a profound pro-inflammatory transcriptomic profile during European winter, with increased levels of soluble IL-6 receptor and C-reactive protein” (Abstract) Dopico XC, Evangelou M, Ferreira RC, Guo H, Pekalski ML, Smyth DJ, Cooper N, Burren OS, Fulford AJ, Hennig BJ, Prentice AM, Ziegler AG, Bonifacio E, Wallace C, Todd JA. 2015. Nature Communications. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. CC BY; credit Dopico et al., Nature Communications 2015