In healthy adults, sessions of fast, deep connected breathing (Holotropic and conscious connected breathwork) bring on altered states of consciousness, with features such as ego dissolution that resemble psychedelic experiences, and the onset of these states tracks the fall in exhaled carbon dioxide caused by deliberate overbreathing.
Who this is about
healthy adults experienced in breathwork
Safety note
The altered states come from deliberate overbreathing, which lowers carbon dioxide in the blood; studies screened out people with heart, lung, seizure and psychotic conditions and people who are pregnant.
Details and sources
Practical note
Graded low: the main evidence is one experimental study of 61 experienced practitioners in which about 70% were randomly assigned to active breathing and 30% to normal breathing in the same session, with several authors trained as facilitators, plus a survey of 48 mental health professionals after a workshop; the physiological link is consistent with a narrative review. Holotropic sessions in the literature last about 1 to 3 hours.
Vegan note
Not diet-related; applies equally to people following a vegan diet.
Sources
- “Participants reported altered states reaching intensity ranges comparable to those described in studies using moderate doses of serotonergic psychedelics.” (Abstract) Lueken U, Dziobek I, Havenith MN, Schild M, Daedelow LS. 2026. npj Mental Health Research. High ventilation breathwork as a non-pharmacological model for inducing psychedelic-like states: expert evaluations of therapeutic potential and risk. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine
- “We show that a reduction in end-tidal CO2 pressure due to deliberate hyperventilation is significantly correlated to ASC onset (r = -0.46; p < 0.001).” (Abstract) Havenith MN, Leidenberger M, Brasanac J, Corvacho M, Carmo Figueiredo I, Schwarz L, Uthaug M, Rakusa S, Bernardic M, Vasquez-Mock L, Pérez Rosal S, Carhart-Harris R, Gold SM, Jungaberle H, Jungaberle A. 2025. Communications Psychology. Decreased CO(2) saturation during circular breathwork supports emergence of altered states of consciousness. CC BY 4.0; credit Havenith et al., Communications Psychology 2025
- “HVB is associated with extraordinary changes in subjective experience, as well as with profound effects on central and autonomic nervous systems functions” (Abstract) Fincham GW, Kartar A, Uthaug MV, Anderson B, Hall L, Nagai Y, Critchley H, Colasanti A. 2023. Neuroscience and Biobehavioral Reviews. High ventilation breathwork practices: An overview of their effects, mechanisms, and considerations for clinical applications. publisher copyright; metadata and short quotes only; Courtesy of the U.S. National Library of Medicine