In randomised trials lasting 12 weeks or longer, adults who ate the larger share of their daily calories earlier in the day lost slightly more weight, about 1.75 kg, than adults who ate more of them later.
Low certainty
Further research is likely to change this.Who this is about
adults in weight-loss trials, most with overweight
Practical note
Graded low: 4 randomised trials with 272 participants, none at low overall risk of bias, and the authors judged the effect small and of uncertain clinical importance. This tests an idea close to the organ-clock teaching of an early, large breakfast; it does not test the organ clock itself.
Vegan note
The trials did not study vegan diets; the timing principle is independent of diet.
Safety note
Shifting calories earlier is low risk for most adults. People who take glucose-lowering medicines and people with a history of disordered eating would discuss changes to meal times with their clinician.
Sources
- Supports “consuming the majority of calories earlier in the day resulted in more weight loss compared with consuming them later in the day (MD, –1.75 kg; 95% CI, –2.37 to –1.13 kg; I 2 = 12%; low-certainty evidence)” (Results, Calorie Distribution) Liu HY, Eso AA, Cook N, O'Neill HM, Albarqouni L. 2024. JAMA Network Open. Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis. CC BY 4.0; credit Liu et al., JAMA Network Open 2024
- Context “None of the included RCTs judged low overall risk of bias” (Results, Risk of Bias) Liu HY, Eso AA, Cook N, O'Neill HM, Albarqouni L. 2024. JAMA Network Open. Meal Timing and Anthropometric and Metabolic Outcomes: A Systematic Review and Meta-Analysis. CC BY 4.0; credit Liu et al., JAMA Network Open 2024